Stem cell Therapy for Knee Pain-Rheumatoid Arthritis
Can stem cell cure arthritis?
Scientists are using stem cells to repair joints and cartilages in the patient suffering from rheumatoid arthritis.
Rheumatoid arthritis is an autoimmune disorder affecting 1 in a hundred people around the world.
Normally, your immune system makes antibodies to attack foreign substances like bacteria and viruses, in Rheumatoid arthritis your immune system mistakenly direct antibodies to the lining of your drawings
This causes inflammation and soreness of the tissues between joints.
Chronic inflammation destroys the nearby bones and cartilages which is the connective tissue that cushions the joints
Its erosion results in severe pain during movement. Over time it becomes harder to run, walk, bend or even put weight on your joints.
Does stem cell therapy really work?
Currently, there is no cure for rheumatoid arthritis but stem cell therapy may soon become a better treatment option for people suffering from this ailment.
unfortunately, it is not as simple as you might hope,
Stem cells are uncommitted cells that have the ability to be converted into another type of human cells.
they are like master cells that can be used to repair any type of tissues in the body.
The most common types of stem cells used for treating Arthritis are mesenchymal stem cells or MSCs
This type of stem cell is usually collected from the patient’s fat tissue blood or bone marrow.
The only FDA approved stem cell therapy for rheumatoid arthritis uses themselves from human umbilical cord tissue as they are more robust than mesenchymal stem cells obtained from other sources.
MSCs suppress immune responses and start producing anti-inflammatory agents which only acts at the site of injury.
Can stem cells repair knee cartilage?
As most stem cells are collected from patients body, the immune system does not recognize them as foreign Invaders, so it does not produce a negative response.
Stem cell therapy with MSCs also produces T regulatory cells which are a type of immune cells that protects the body against immunological self-attack.s
Once stem cells are programmed they can be delivered through injections into the patient’s blood or joints.
This forms a Framework upon which stem cells can multiply and form new cartilage to replace the injured tissue.
Another method of transferring stem cells involves surgery.
In the surgical treatment, joint surfaces are exposed and stem cells are transplanted.
Growth factors are supplementary to enhance the healing process.
in a clinical trial, 172 patients were divided into two groups,
One group received regular R A medication while the other received MScs treatments
Those receiving MScs showed significant and persistent improvement in their condition, however treating RA with stem cells is still experimental, which means there is a certain risk involved in the therapy.
Is stem cell therapy successful?
The problem with stem cells is that the cells can continue to evolve.
These can divide many times and differentiate into many cell types increasing the chances that a tumor will form. Also, MSCs suppress the immune system making the environment more favorable for cancer cells to grow.
A 2014 review shows that treating arthritic joints with MSCs may worsen the condition.
Intravenous injection of MSCs into joints triggers the development of special cells that play a role in joint inflammation and destruction, so all things considered, this research is far from over.
Though, one thing is certain, stem cells used in treating ailments will only continue to become more prevalent as time goes on because of their incredible versatility.
With any luck, we will find a way to mitigate the risks in stem cell therapies and be able to heal secure injured people using these amazing cells from their very own bodies.
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